The growing prevalence of drugs trafficking, substance abuse and other drug-related crimes poses significant concerns to Liberia’s peace, security, public health, and socio-economic credentials of the country. The Liberia Drugs Enforcement Agency (LDEA) plays a crucial role in mitigating the menace of drug-related crimes, enhancing surveillance, intelligent gathering, case management and operational efficiency. Consequently, challenges hindering the implementation of technology-driven solution in (LDEA) includes outdated enforcement strategies, limited resources, legal constraints and weak intelligence-sharing techniques. This research analyzes the role of technology in strengthening the LDEA’s capacities in curtailing the drugs trafficking and substance abuses by examining modern enforcement tools such as artificial intelligence (AI), surveillance drones, blockchain technology, digital forensics, and cybersecurity measures. The study employs mixed method approach, combining qualitative data from interview and quantitative data through drugs-related crime trends, arrests rates and the effectiveness of technology-driven equipment. The findings contribute to the discourse of drugs law enforcement modernization in Liberia, providing policy recommendations on how to integrate advanced technology into drugs law enforcement operations. Subsequently, the results underscore the importance of capacity building, inter-agency synergy and collaboration and international partnership to extend the benefits of technology in drug control.